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BMP · Bone Graft

Helping bones grow back stronger

NOVOSIS — a next-generation bone graft for spine surgery and serious fractures.

Some injuries and surgeries need extra help to heal. NOVOSIS delivers a natural bone-building protein right where it’s needed, so your body can grow new bone.

The science

What is BMP?

BMP stands for Bone Morphogenetic Protein. It’s a protein your body already makes to signal where new bone should grow. BMP-2 is one of the strongest of these signals. It calls in the body’s repair cells and turns them into new bone.

The name says it all
NOVOnew
+
OSbone
+
SISgenesis
NOVOSISNew bone, from the beginning.
How NOVOSIS works

A slow, steady boost for bone healing

NOVOSIS combines two parts:

rhBMP-2

The bone-building protein, made in a laboratory.

Hydroxyapatite granules

A porous, bone-like mineral that acts as a scaffold and carrier.

Protein releaseup to 28 days
Day 0Day 7Day 14Day 21Day 28

Illustration of a slow, steady release — not measured data.

The granules hold the protein and release it slowly, for up to 28 days. New bone grows through the scaffold and joins up with the surrounding bone. Because the release is steady, only a low dose is needed.

When is it used?

Where NOVOSIS can help

Spine fusion surgery

Helping two vertebrae in the lower back grow together into one solid bone.

Bone loss from injury

Filling gaps in bone after a serious fracture from an accident.

What makes it different

Why NOVOSIS?

Grows new bone

Actively signals your body to form bone, not just fill a gap.

Slow, controlled release

Protein released steadily for up to 28 days.

Lower dose

The slow-release carrier means less BMP is needed.

An alternative to taking bone from your hip

Surgeons can use it instead of, or together with, bone taken from your own hip, which would otherwise mean a second wound.

Strong scaffold

Porous granules (about 80% porosity) give new bone room to grow.

Is NOVOSIS right for me?

NOVOSIS is used by experienced surgeons during an operation. If you’re planning spine surgery or have a fracture that is slow to heal, ask your surgeon whether a bone graft like NOVOSIS is suitable for you.

FAQ

Frequently asked questions

Is NOVOSIS a medicine I take?

No. It is placed directly at the bone during surgery by your surgeon.

It is made in a laboratory using recombinant technology. It is not taken from a human or animal donor.

That depends on your surgery. Your surgeon will decide the best approach.

For healthcare professionals

NOVOSIS specifications

Composition
E. coli-derived rhBMP-2 + porous hydroxyapatite granules (70% macro + 10% micro porosity, ~300 µm pores).
Indications
Posterior instrumentation and lumbar posterolateral fusion (L1–S1); bone defects from traumatic acute fracture.
Sizes
0.5 mg / 0.5 g1 mg / 1 g3 mg / 3 g
GL granules 1.0–3.0 mmGE granules 3.0–6.0 mm
Release
Sustained rhBMP-2 release up to 28 days (in vitro).
Manufacturer
CGBio Co., Ltd., Korea.
Internal note: per client, no clinical results or case photos for NOVOSIS on the site.